Cyclohexylamine is an organic compound with the chemical formula of C6H13N. It is a colorless to yellow liquid, soluble in water and miscible in most organic solvents. It is mainly used as a solvent, and can also be used to produce desulfurizer, rubber antioxidant, vulcanization accelerator, plastic and textile chemical additives, boiler water treatment agent, metal corrosion inhibitor, emulsifier, preservative, antistatic agent, latex coagulant, petroleum additive, bactericide Insecticide and dye intermediates.

Chinese name Cyclohexylamine foreign name

Alias hexahydroaniline

Chemical formula C6H13N, molecular weight 99.174

CAS Login No. 108-91-8

EINECS Login No. 203-629-0

Melting point – 17 ℃

Boiling point 134 ℃ Water solubility Soluble

Density 0.867 g/cm ³

Colorless to yellow liquid

Flash point 26 ℃ (CC)

Safety description S1/2; S36/37/39； S45

Hazard symbol C

Hazard description R10; R21/22； R34

essential information

Chemical formula: C6H13N

Molecular weight: 99.174

CAS No.: 108-91-8

EINECS No.: 203-629-0

Physical and chemical properties

Density: 0.867g/cm3

Melting point: – 17 ℃

Boiling point: 134 ℃

Flash point: 26 ℃ (CC)

Critical pressure: 4.2MPa

Ignition temperature: 293 ℃

Refractive index: 1.459 (20 ℃)

Saturated vapor pressure: 1.2kPa (20 ℃)

Upper explosive limit (V/V): 9.4%

Lower explosive limit (V/V): 1.5%

Appearance: colorless to yellow liquid

Solubility: soluble in water, miscible in most organic solvents

Molecular Structure Data

Molar refractive index: 31.22

Molar volume (cm3/mol): 114.0

Isotonic specific volume (90.2K): 270.1

Surface tension (dyne/cm): 31.4

Polarization ratio (10-24cm3): 12.37

Calculate chemical data

Reference value of drainage parameter calculation (XlogP): None

Number of hydrogen bond donors: 1

Number of hydrogen bond receptors: 1

Number of rotatable chemical bonds: 0

Number of tautomers: 0

Topological molecular polar surface area: 26

Number of heavy atoms: 7

Surface charge: 0

Complexity: 46.1

Number of isotope atoms: 0

Determine the number of atomic stereocenters: 0

Number of uncertain atomic stereocenters: 0

Determine the number of chemical bond stereocenters: 0

Number of uncertain chemical bond stereocenters: 0

Number of covalent bond units: 1

Toxicological data

1. Acute toxicity

LD50: 11mg/kg (rat oral); 227mg/kg (rabbit skin)

LC50: 7750mg/m3 (inhalation by rats)

2. Irritation

Human percutaneous: 125mg (48h), severe stimulation.

3. Mutagenicity

DNA inhibition: human Hela cell 100 μ g/L。

Dominant lethal test: mice abdominal cavity 500mg/kg.

Cytogenetic Analysis: Human Leukocyte 10 μ mol/L（5h）。

4. Carcinogenicity

IARC carcinogenicity review: G3, insufficient evidence of carcinogenicity to humans and animals.

5. Other

The lowest oral toxic dose (TDLo) of rats: 5600mg/kg (4 weeks before male mating), which affects sperm.

The lowest oral toxic dose (TDLo) of mice: 600mg/kg (administered on the 6th to 11th day of pregnancy), the mortality after blastocyst implantation increased, and the fetal mice died.

Ecological data

1. Ecotoxicity

LC50: 90mg/L (96h) (rainbow trout, static)

EC50: 20mg/L (96h) (green algae); 80mg/L (24h) (Daphnia)

2. Biodegradability

MITI-I test showed that the initial concentration was 100ppm, the sludge concentration was 30ppm, and the degradation rate was 61.1% after 2 weeks.

3. Non biodegradable

In air, when the concentration of hydroxyl radical is 5.00 × At 105/cm3, the half-life of degradation is 7h (theoretical). [1]

Purpose

It is mainly used as solvent and can also be used to produce desulfurizer, rubber antioxidant, vulcanization accelerator, plastic and textile chemical additives, boiler water treatment agent, metal corrosion inhibitor, emulsifier, preservative, antistatic agent, latex coagulant, petroleum additive, bactericide, insecticide and dye intermediate.

First aid measures

Skin contact: Take off contaminated clothes immediately, and wash with plenty of flowing water for at least 15 minutes. Get medical attention.

Eye contact: immediately lift the eyelids and wash them thoroughly with a large amount of flowing water or normal saline for at least 15 minutes. Get medical attention.

Inhalation: quickly leave the site to a place with fresh air. Keep the respiratory tract unobstructed. If breathing is difficult, give oxygen. If breathing stops, perform artificial respiration immediately. Get medical attention.

Ingestion: Rinse with water and drink milk or egg white. Get medical attention.

Fire fighting measures

Hazardous combustion products: carbon monoxide, carbon dioxide, nitrogen oxide.

Extinguishing method: spray the escaping liquid with water to dilute it into an incombustible mixture, and protect firefighters with foggy water.

Extinguishing agent: water, insoluble foam, dry powder, carbon dioxide, sand.

Leakage emergency treatment

Evacuate the personnel in the contaminated area to a safe area quickly, isolate them, and strictly restrict access. Cut off the ignition source. It is recommended that emergency treatment personnel wear self-contained positive pressure respirators and acid and alkali resistant work clothes. Enter the site from the upwind. Cut off the source of leakage as much as possible. Prevent flowing into restricted spaces such as sewers and flood drainage ditches.

Small amount of leakage: mix with sand, dry lime or soda ash. A large amount of water can also be used for flushing, and the diluted washing water will be put into the wastewater system.

Large amount of leakage: build a dike or dig a pit to receive. Cover with foam to reduce steam disaster. Use explosion-proof pump to transfer to tank car or special collector for recycling or transport to waste disposal site.

Handling and storage

Precautions for operation: close operation, pay attention to ventilation. The operators must be specially trained and strictly abide by the operating procedures. It is recommended that operators wear direct gas masks (half masks), chemical safety goggles, anti-corrosion work clothes and rubber oil resistant gloves. Keep away from kindling and heat sources. Smoking is strictly prohibited in the workplace. Use explosion-proof ventilation systems and equipment. Prevent steam from leaking into the air of the workplace. Avoid contact with acids. Handle with care to prevent damage to packaging and containers. Fire fighting equipment and leakage emergency treatment equipment of corresponding varieties and quantities shall be provided. Empty containers may retain harmful substances.

Storage precautions: Store in a cool and ventilated warehouse. Keep away from kindling and heat source. The warehouse temperature should not exceed 30 ℃. Keep container sealed. It shall be stored separately from acids and edible chemicals and shall not be mixed. Explosion proof lighting and ventilation facilities shall be adopted. It is prohibited to use mechanical equipment and tools that are easy to generate sparks. The storage area shall be equipped with leakage emergency treatment equipment and appropriate materials.

Safety information

Safety terminology

S1/2：Keep locked up and out of the reach of children.

Keep it locked and away from children.

S36/37/39：Wear suitable protective clothing, gloves and eye/face protection.

Wear appropriate protective clothing, gloves and goggles or masks.

S45：In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible).

In case of an accident or discomfort, seek medical advice immediately (show the label if possible).

Risk terminology

R10：Flammable.

Flammable.

R21/22：Harmful in contact with skin and if swallowed.

Harmful in contact with skin and if swallowed.

R34：Causes burns.

Causes burns.